Design and Evaluation of Screening Workflows for Pharmacodynamics Studies

The objective of this project was to develop a pharmacodynamic biomarker discovery workflow capable of identifying and evaluating biomarkers to support future clinical studies for the SAB05 antibody-drug conjugate program. Proteomic and transcriptomic techniques were evaluated based on scientific rigor and practical considerations, including cost, scalability, and turnaround time. The workflow established a framework for biomarker discovery and prioritized established platforms to streamline implementation and validation. The findings of this project provided a foundation for upcoming technology transfer to contract research organizations and contributed to ongoing assay development.