Capstone Projects

Optimizing the Production and Scale up of Magnetic Streptavidin Resin for Biotin Binding Applications

Program: Applied Biotechnology Master's Degree — Research and Development
Host Company: Promega
Location: Fitchburg, Wisconsin (onsite)
Student: Ashley Jo Pratt

The objective of my project was to optimize the manufacture of a current product within my department. After multiple batches failed by multiple different scientists, determining a root cause for the failures was paramount. Testing for a root cause led to other possible changes to streamline the manufacture. A need for scaling up the manufacture resulted in a change in lab space, improvements in practices for safety and efficiency, and a thorough understanding of the preparation and execution of the manufacture at a novel scale.